Overexpression of MYC and EZH2 cooperates to epigenetically silence MST1 expression
نویسندگان
چکیده
منابع مشابه
DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression
DOT1L has emerged as an anticancer target for MLL-associated leukaemias; however, its functional role in solid tumours is largely unknown. Here we identify that DOT1L cooperates with c-Myc and p300 acetyltransferase to epigenetically activate epithelial-mesenchymal transition (EMT) regulators in breast cancer progression. DOT1L recognizes SNAIL, ZEB1 and ZEB2 promoters via interacting with the ...
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ژورنال
عنوان ژورنال: Epigenetics
سال: 2014
ISSN: 1559-2294,1559-2308
DOI: 10.4161/epi.27957